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Title Automated adjustment of inspired oxygen in preterm infants with frequent fluctuations in oxygenation: a pilot clinical trial.
Author(s) Claure N, D'Ugard C, Bancalari E.
Source J Pediatr, Vol. 155, No. 5, Pages 606-608
Publication Date Nov. 2009
Abstract OBJECTIVE: To assess the efficacy of a system for automated fraction of inspired oxygen (FiO(2)) adjustment in maintaining oxygen saturation (SpO(2)) within an intended range in preterm infants with spontaneous fluctuations in SpO(2). STUDY DESIGN: Sixteen infants (gestational age, 24.9 +/- 1.4 weeks; birth weight, 678 +/- 144 g; age, 33 +/- 15 days) with frequent hypoxemia episodes underwent two 4-hour periods of FiO(2) adjustment by clinical personnel (routine) and the automated system (automated). RESULTS: Compared with the routine period, the percent time within intended SpO(2) range (88%-95%) increased during the automated period (58% +/- 10% versus 42% +/- 9%; P < .001), whereas the percent time with SpO(2) higher than the intended range and >or=98% were reduced (9% +/- 10% versus 31% +/- 8% [P < .001] and 3% +/- 5% versus 16% +/- 9% [P < .001], respectively). Percent time with SpO(2) < 88% increased during the automated period (33% +/- 7% versus 27% +/- 9%; P = .003) because of more frequent episodes, whereas the time with SpO(2) < 75% did not differ. The 4-hour median FiO(2) was lower during the automated period (29% +/- 4% versus 34% +/- 5%; P < .001). CONCLUSION: Automated FiO(2) adjustment improved maintenance of SpO(2) within the intended range and reduced hyperoxemia and FiO(2). These findings should be examined in longer periods with standard clinical conditions and, eventually, in the context of randomized trials powered to detect clinically important effects on outcome.


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