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Title Pharmacodynamics of Mivacurium in Infants
Author(s) O.A. Meretoja, T. Taivainen, K. Wirtavuori
Source British Journal of Anaesthesia, Vol. 73, Pages 490-493
Publication Date 1994
Abstract A computerized infusion system was used to determine mivacurium infusion requirements to maintain 95% and 50% neuromuscular blockade in 15 infants less than 1 year of age. Neuromuscular block was measure by adductor pollicis EMG and anaesthesia maintained with 66% nitrous oxide in oxygen and alfentanil 50-100 mcg/kg/h. Neuromuscular block was produced by repeated bolus doses of mivacurium 0.1 mg/kg; subsequently the target neuromuscular block was maintained by a closed loop infusion. Dose potency of mivacurium was similar to that previously published in children with a similar anaesthetic technique. Mean mivacurium requirement for 95% neuromuscular block was 820 (SD 300) mcg/kg/h, which represented an hourly requirement of 6.6 (1.5) individual ED95 doses. Infusion requirement for 50% neuromuscular block was 320 (150) mcg/kg/h. These infusion rates were similar to those in children. No side effects of mivacurium were noticed.

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